5 Best Supplements for Adrenal Fatigue

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Do you feel exhausted all the time, no matter how much sleep you get? Do you find it hard to focus or concentrate on anything? If so, you may be suffering from adrenal fatigue.

This is a condition that affects many people today, and can cause a wide range of symptoms.

Luckily, there are several supplements that can help improve adrenal function and alleviate the symptoms of fatigue.

In this blog post, we will discuss the best supplements for adrenal fatigue.

Keep in mind supplements are lightly regulated by the FDA. Their stated claims have no guarantee. They aren’t cures or treatments for any diseases.

Please check with your doctor before starting any supplement program and that we include items that we trust will be useful to our visitors. If you click one of the links on our site, we may get a commission.

If you have questions see the FAQ section below – now let’s dive in!

Best Overall – Nature’s Nutrition

  • Price = $31.99
  • # of Servings = 30
  • Price per Serving = $1.06
  • Product Reviews = 4.4/5 (520 reviews)
  • Serving Size = 2 Capsules
  • Taste / Absorbability = Unflavored 
  • Labeled Effect = Support your adrenal health and daily energy
  • Food Allergens = Gluten free, Safe
  • Pros = Amazon’s Choice for “adrenal support supplements”
  • Cons = A bit higher price per serving

About Adrenal Support

If you are looking for a natural way to support your adrenal health, try Nature’s Nutrition Adrenal Support supplement. This supplement has been scientifically formulated to support your adrenal health and daily energy levels.

The natural herbs, including Ashwagandha, Holy Basil, Rhodiola Rosea, Licorice Root, and other herbs, are chosen for their premium quality and effectiveness. BioPerine is included for improved absorption.

As Amazon’s Choice for “adrenal support supplements”, this is a safe choice if you’re looking for a popular and proven supplement.

Made by Nature’s Nutrition:

Nature’s Nutrition – Top quality products, exceptional service, best value at affordable prices. According to ReviewMeta.com, Nature’s Nutrition has a 4.2 average adjusted rating with 1,813 verified reviews.

  • Revenue = $5 million
  • Employees = 25
  • Third Party Certifications = GMP, GMO free
  • Third Party Reviews = 4.2 average adjusted rating with 1,813 verified reviews

Best for Adrenal Cortex – Pure Encapsulations

  • Price = $18.30
  • # of Servings = 30
  • Price per Serving = $0.61
  • Product Reviews = 4.5/5 (1,373 reviews)
  • Serving Size = 2 Capsules
  • Taste / Absorbability = Unflavored 
  • Labeled Effect = Support for healthy adrenal function
  • Food Allergens = Safe
  • Pros = Also supports healthy cortisol levels
  • Cons = No other vitamins, minerals or herbs

About Adrenal

Looking for a way to support your adrenal glands and function? Pure Encapsulations Adrenal is a unique supplement is designed to provide nutritional support for healthy adrenal function, as well as cortisol support.

Made with only premium ingredients, Pure Encapsulations Adrenal and other products are free from wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.

Made By Pure Encapsulations:

Pure Encapsulations began in 2004. According to ReviewMeta.com, Pure Encapsulations has a 4.5/5 average rating from 12,280 reviews. Pure Encapsulations lists over 50 clinical studies going back to 2006 on their website.

  • Start = 2004
  • Revenue = $35 million
  • Employees = 170
  • Mission = it’s what’s inside that counts
  • Third Party Certifications = Egg Free, Gluten Free, GMO Free, GMP, Certification Made in the USA, Peanut Free, Wheat Free, Hypoallergenic, NSF
  • Third Party Reviews = 4.3/5 with 7,100 reviews

Best for Phytisone – Thorne

  • Price = $19.00
  • # of Servings = 30
  • Price per Serving = $0.63
  • Product Reviews = 4.7/5 (38 reviews)
  • Serving Size = 2 Capsules
  • Taste / Absorbability = Unflavored 
  • Labeled Effect = Helps manage the effects of stress and reduce fatigue
  • Food Allergens = Safe
  • Pros = High quality and diverse blend of ingredients for stress relief
  • Cons = Fewer reviews

About Phytisone

Looking to manage the effects of stress and reduce fatigue? Thorne Phytisone may be just what you need! Phytisone is a unique, non-glandular formula of botanicals and nutrients designed to help optimize the adrenal gland’s response to stress.

When we encounter a threat, our adrenal glands release cortisol, epinephrine, norepinepinephrine, and other chemicals that raise our heart rate, blood pressure, and blood sugar while constricting blood vessels to the digestive tract.

This “fight or flight” reflex can be a lifesaver. However, the constant low-level stress most of us feel today – together with environmental pollution and diets high in refined carbohydrates – can overstimulate and overtax our adrenal glands. This can damage our immune, cardiovascular, neurological, and endocrine systems – and our long-term health.

Phytisone helps support healthy adrenal function by providing nourishing botanicals and nutrients that promote energy production, detoxification, and healthy cortisol levels.

If you’re looking for a supplement blend to support healthy adrenals this is a safe choice.

Made By Thorne:

Founded in 1984 and based out of New York. According to ReviewMeta.com, Thorne Research gets a 4.4/5 average adjusted rating from 8,718 verified reviews.

  • Start = 1984
  • Revenue = $171 million
  • Employees = 496
  • Mission = empower individuals to live healthier for longer through personalized, scientific testing and solutions
  • Third Party Certifications = NSF, cGMP, TGA
  • Third Party Reviews = 4.4/5 average adjusted rating from 8,718 verified reviews

Most Unique Proprietary Formula – Life Extension

  • Price = $18.00
  • # of Servings = 30
  • Price per Serving = $0.60
  • Product Reviews = 4.5/5 (41 reviews)
  • Serving Size = 2 Vegetarian Capsules
  • Taste / Absorbability = Unflavored 
  • Labeled Effect = Enhances energy, stamina and quality of life
  • Food Allergens = Safe
  • Pros = Proprietary formula has advantages in being unique
  • Cons = Fewer reviews, ingredients lesser known

Adrenal Energy Formula

If you’re looking for a natural way to support your body’s response to stress, try the Life Extension Adrenal Energy Formula.

The Adrenal Energy Formula combines four stress-stopper extracts: holy basil, cordyceps, bacopa, and ashwagandha, all of which have been clinically proven to assist with a healthy response to stress.

This unique blend of botanical extracts is designed to help your body maintain its state of homeostasis, even when under stress. This formula may help you keep your energy levels up and your focus sharp. So if you are looking for a unique, proprietary herbal supplement to help with adrenal fatigue this is a safe choice.

Made by Life Extension:

Life Extension began in 1980 and is still going 40 years later. In 2021 ConsumerLab.com voted Life Extension as #1 Rated Catalog/Internet Merchant. According to ReviewMeta.com, Life Extension’s average adjusted rating of 4.1/5 from 24, 224 verified reviews. 

  • Start = 1980
  • Revenue = $168 million
  • Employees = 500
  • Mission = Achieve your goals with the best nutritional products that science can offer
  • Third Party Certifications = GMP, Non-GMO
  • Third Party Reviews = average adjusted rating of 4.1/5 from 24, 224 reviews

Best Scientific Support – Neuro Science

  • Price = $70.30
  • # of Servings = 60
  • Price per Serving = $0.28
  • Product Reviews = 4.7/5 (267 reviews)
  • Serving Size = 3 Capsules
  • Taste / Absorbability = Unflavored 
  • Labeled Effect = Support adrenal health and reducing stress-induced fatigue
  • Food Allergens = Safe
  • Pros = Some scientific support
  • Cons = 3 capsule serving size

About AdreCor

Introducing Neuro Science AdreCor, a supplement for anyone looking to support their adrenal health and reduce stress-induced fatigue.

With important ingredients for adrenal health and reducing stress-induced fatigue, AdreCor has been pioneering the concept of neuro adrenal support supplements since 2003.

AdreCor contains Green Tea Extract, which is rich in polyphenols like EGCG. Fight energy slumps and tackle fatigue with EGCG, which has been shown to increase resistance to fatigue. Additionally, Rhodiola rosea has been shown to significantly improve mental fatigue and general well-being under stress.

Finally, stay sharp and conquer ‘brain fog’ with amino acids like L-Tyrosine and L-Theanine, which have been shown to support cognitive function and healthy stress response.

Overall, with a potent blend of ingredients like Rhodiola Rosea, Vitamin C, Green Tea Extract, and amino acids like L-Tyrosine and L-Theanine, AdreCor is your a safe bet for reducing fatigue, brain fog, and stress.

Made By Neuroscience:

Neuroscience has been around for 20 years. They have a strong scientific foundation. According to ReviewMeta.com, Neuroscience gets an adjusted average score of 4.0/5 with 854 verified reviews.

  • Start = 2000
  • Revenue = $5 million
  • Employees = 28
  • Mission = delivering supplements that contain impactful amounts of ingredients in a practical daily serving
  • Third Party Certifications = cGMP
  • Third Party Reviews = adjusted average score of 4.0/5 with 854 reviews

What factors do we use to rank supplements?

1 – Price: What’s the price of the supplement? What’s the cost per serving? At Eating Enlightenment we value quality over price. However, all else being equal, then price comes into consideration. 

2 – Reviews: How many reviews for each product? What’s the average rating? How many third party reviews? We strongly believe in third party reviews. Many supplement companies list positive reviews on their website, but third party reviews include negative comments. We always go with third party reviews.

3 – Reputation: How reputable is the brand behind the supplement? How long has the brand been around? What’s their mission? We believe that a company’s intention is highly important and should be one of your top purchasing decision factors.

4 – Taste / Absorption = What’s the taste? How quickly does your body absorb the supplement? Do reviews mention any negative side effects like an upset stomach?

5 – Perceived Therapeutic Effect = What beneficial effects or feelings does this supplement promote?

6 – Food Allergens = Does the company provide allergen info?

7 – Science / Certifications: Does the company list transparent scientific studies on their website? Do third party certifications test the company’s supplement for quality control? How many certifications does the company have?

8 – Pros/Cons: What are the pros and cons of each supplement? How is the supplement unique? For what situations is this supplement best?

What causes adrenal fatigue?

There are a variety of causes of adrenal fatigue, but the most common is stress.

When we are under constant stress, our adrenal glands become exhausted and can no longer produce the hormones we need to function properly.

However, adrenal fatigue is a condition that can be caused by a variety of factors, including stress, poor diet causing vitamin deficiencies, and lack of sleep.

What are the symptoms of adrenal fatigue?

The symptoms of adrenal fatigue include fatigue, difficulty concentrating, irritability, and cravings for sugary or salty foods.

These symptoms can lead to a whole host of problems, including fatigue, anxiety, depression, and even weight gain.

Top 14 Symptoms of Vitamin Deficiency

Who benefits most from adrenal fatigue supplements?

Anyone can develop adrenal fatigue, but it is more common in people who are under a lot of stress.

According to many experts, those who suffer from adrenal fatigue can often benefit the most from supplementation.

This is because when our adrenals are fatigued, they are not able to produce the necessary hormones and compounds needed for optimal health. By supplementing with key nutrients and minerals, we can help give our bodies the support it needs to function at its best.

Who may not benefit from adrenal fatigue supplements?

If you are not under a lot of stress, have a good diet, and get enough sleep, you may not need adrenal fatigue supplements.

However, if you are under a lot of stress or have other risk factors for adrenal fatigue, supplements may be helpful in addition to other lifestyle changes.

Risks, side effects and other precautions?

Taken as directed, adrenal fatigue supplements are generally safe. However, as with any supplement, there are a few risks and side effects to be aware of.

The most common side effect is upset stomach. If you experience any other side effects, stop taking the supplement and consult your doctor.

When should I take adrenal fatigue supplements?

There is no one-size-fits-all answer to this question.

However, many experts recommend taking adrenal fatigue supplements in the morning or early afternoon.

This is because our bodies are better able to absorb and utilize the nutrients during the day when stress levels are typically higher.

Food sources for adrenal fatigue

  • leafy greens
  • cruciferous vegetables
  • healthy fats
  • protein
  • nuts and seeds
  • turmeric

Foods to avoid:

  • sugar
  • caffeine
  • alcohol

How can I reduce adrenal fatigue quickly?

There are a few lifestyle changes you can make to support your adrenal health. First, try to reduce the amount of stress in your life.

This may mean cutting back on work hours or taking some time for yourself each day.

Second, eat a healthy diet that includes plenty of fresh fruits and vegetables, healthy fats, and protein.

Finally, get enough sleep each night. If you are struggling to get enough rest, consider taking an sleep supplement before bedtime.

While there is no cure for adrenal fatigue or chronic stress, these lifestyle changes can help you feel better and improve your overall health.

How soon after taking adrenal fatigue supplements will I feel better?

University of Wisconsin pharmacy professor Michael E. Smith, says that “it typically takes two to three weeks” for patients to start feeling the effects of adrenal fatigue supplements.

So if you’re feeling stressed out and run down, it’s worth giving them a try! Just be sure to talk to your doctor first.

Best Supplement for Adrenal Fatigue Conclusion

Adrenal fatigue is a condition that is caused by stress and can lead to a number of other health

While there is no magic cure for stress related fatigue, there are a few things you can do to help support your adrenal health, including reducing stress levels, eating a healthy diet, and getting enough sleep.

Supplements may also be helpful in restoring balance and supporting optimal health. If you are struggling with adrenal fatigue, it’s worth giving supplements a go.

Read our beginner’s guide to supplements and research our supplement database to find what you’re looking for!

Do you have any additional questions? Leave a comment down below!

About the Author

Jared Levenson is a former binge eating wrestler turned Zen Buddhist Monk, Internal Family Systems counselor and nutrition wellness coach. He's helped hundreds of people through universal meal principles and internal family systems to make peace with food, stop binge eating, and find true health and wholeness.


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